Synthesis and biological activity of C-3' ortho dihydroxyphthalimido cephalosporins.
نویسندگان
چکیده
A series of C-3' ortho dihydroxyphthalimido cephalosporins 3-7 has been prepared by reaction of C-3' aminomethyl cephalosporin 41 with the corresponding N-carboethoxyphthalimides 23-25, 37, 38. These new cephalosporins exhibit excellent in vitro Gram-negative activities, including Pseudomonas aeruginosa, excellent beta-lactamases stability and pharmacokinetics equivalent or better than ceftriaxone.
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عنوان ژورنال:
- The Journal of antibiotics
دوره 46 9 شماره
صفحات -
تاریخ انتشار 1993